Role of Creatine Kinase MB in Diagnosis of Myocardial Injury after Neonatal Hypoxia-Ischemia

Background: Creatine kinase MB (CK-MB), which exists mainly in the cytoplasm of myocardial cells, is currently accepted as an indicator and has high sensitivity specificity for diagnosis injury. Objective: This study was aimed to estimate serum creatine (CK-MB) levels after asphyxia-induced injury neonates. Patients methods: 40 neonates were included this divided into 20 cases with perinatal hypoxia ischemia controls admitted Neonatology Unit Pediatric Department at Zagazig University.  Serum CK-MB estimated all studied   Results: In present significantly higher than controls. A significant area under curve cutoff >14.5 (units /L) 99%and 97.5% CK-MB.  Encephalopathy associated HR CKMB. Cases organ failure metabolic acidosis CKMB. Conclusion: It could be concluded that hypoxic ischemic encephalopathy (HIE) those multiple had a more pronounced elevation compared hypoxia-ischemia no failure. Similarly, patients HIE cardiac enzymes. Collectively, these findings indicate systolic dysfunction damage